601-855-3133 or 1-888-844-3577 are the numbers you can call to file your unemployment claim by telephone or to call if you have questions about your existing claim. Our call center is open to assist you with your unemployment needs Monday through Friday 8:00 a.m until 5:00 p.m. If you have been asked to submit documentation relative to your claim, our mailing address is Mississippi Department of Employment Security, P.O. Box 125, Jackson, MS 39205-0125.